Montwrobleski77

Collectively Cleft Lip and Cleft Palate has a major clinical impact requiring surgical, dental, orthodontic, speech, hearing and psychological treatments or therapies throughout childhood

The genetic basis of cleft lip with or without cleft palate remains unresolved

Population-based candidate-gene studies can be an effective strategy for identifying genes involved in the etiology of disorders

Preterm cleft children with low birth weight should be screened for the presence of other birth defects

Maternal cigarette smoking during pregnancy as a risk factor for having a child with cleft lip/palate has been suggested by several epidemiologic studies

There have been several investigations assessing the prevalence of associated malformations in geographically defined populations

Some techniques eliminate the severe cleft nasal deformity seen in many secondary cases

The high frequency of associated anomalies has obvious implications for the genetic counseling offered to all patients at cleft palate and craniofacial centers

It is suggested that maternal smoking is one of many factors of importance in the etiology of cleft lip and cleft palate in humans

Possible risks of Cleft Lip and Cleft Palate should be considered when prescribing certain medications for women in their reproductive years