sachinkokil

Catharanthus roseus, family Apocynaceae is a large deciduous plant. The present work highlights the use of vinca flower extract as acid base indicator in different types of acid base titration. The equivalence points obtained by the fruit extract coincident with the equivalence point obtain by standard indicator. This natural indicator is found to be a very useful, economical, simple and accurate for said titration.

A simple synthetic route for the preparation of glycolamide ester conjugates of Niflumic acid is exploited and prepared 2-(-trifluro-m toluidino) nicotinyl glycolamide esters in good yields and their structures were confirmed by various spectral data.Preliminary evaluation of physicochemical and in vitro reversion properties of various prodrugs is studied which includes solubility, lipophilicity, chemical hydrolysis, pH-hydrolysis, enzymatic hydrolysis, and stability study.