Mesothelioma Clinical Trial-An overview of three important clinical trials
Clinical trials are used to find out whether the treatment is safe for general use and whether it is actually effective against diseases. Participation in clinical trials is an important treatment option for many patients with mesothelioma as much of the currently used treatments offer little hope for a cure.
Mesothelioma is very resistant to treatment and medical experts believe that there could be an epidemic of mesothelioma cases in years to come. Clinical trials (research studies with people) are designed to find new treatments and better ways to use current treatments, raising hope for victims of this devastating disease. These are three important ongoing clinical trials for mesothelioma treatment.
1-Phase III Vorinostat (SAHA) clinical trial for progressive or relapsed malignant pleural mesothelioma patients. This trial is studying the use of chemotherapy drug vorinostat to kill cancerous cells and stop their division, it is also believed that the drug can inhibit enzymes that are needed by the cancerous cells for growth and multiplication. These studies are currently in the third phase to understand its effects on epithelial, sarcomatous, and recurrent mesothelioma. Phase III Vorinostat (SAHA) trials for progressive or relapsed malignant pleural mesothelioma patients are currently underway at the Jonsson Comprehensive Cancer Center at UCLA and Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support, Bethesda, Maryland.
2-Phase II AZD2171 clinical trial for patients with unresectable malignant mesothelioma Phase II AZD2171 for patients with unresectable malignant mesothelioma is investigating the use of chemotherapy drugs to inhibit enzymes that slow the growth and block the supply of blood into the cancerous cells. Cancer cells depend on the formation of new blood vessels to bring blood that will supply the nutrients that they need for growth, new drugs are being studied that will inhibit the development of these new blood vessels. This study hopes to result in the development of drugs that will be used to treat epithelial, sarcomatous, advanced, and recurrent malignant mesothelioma. These clinical trials are underway in Arizona, Georgia, Illinois, Indiana, Iowa, Kansas, Massachusetts, Michigan, Missouri, Montana, North Carolina, Ohio, South Carolina, Tennessee, Virginia, Washington, and Wyoming.
3-Phase II clinical trial on the use of Pemetrexed Disodium with Gemcitabine or Carboplatin in advanced malignant mesothelioma patients. The Phase II clinical trial on the use of Pemetrexed Disodium with Gemcitabine or Carboplatin in advanced malignant mesothelioma patients clinical is a study to study the effects of chemotherapy drugs pemetrexed disodium, gemcitabine, and carboplatin on advanced and recurrent malignant mesothelioma. This study is in phase II and is being conducted in several locations across the country including Delaware, Florida Illinois, Indiana, Iowa, Maryland, Michigan, New Jersey, New York, Ohio, Pennsylvania, South Dakota, and Wisconsin.
Mesothelioma victims should always endeavor to ask their oncologist about available clinical trials in their area.
Questions and Answers
Mesothelioma is a deadly cancer with no cure. The symptoms, which usually mimic less-serious illnesses, make the cancer difficult to diagnose. Mesothelioma is a cancer that most people don't even know they have until 20 or 50 years after exposure to the cancer causing agent.
Mesothelioma is a devastating malignancy in the lining of the lungs and other internal organs. It affects about 2,500 Americans annually, most of them industrial workers who came in contact with the toxic mineral asbestos 20 to 50 years ago. Because the prognosis is generally poor for mesothelioma there are a number of clinical trials underway to find more effective treatments.
Recently two antifolate-based combinations with apparently higher efficacy than older regimens have emerged: the pemetrexed/cisplatin regimen and the raltitrexed/oxaliplatin regimen
Mesothelioma is a type of cancer caused by exposure, either primary or secondary, to asbestos. There are many treatment centers in the USA. Mesothelioma is a rare cancer which affects specific membranes of the body.
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Cancer translational research brings together scientists' and clinicians' suggestions to develop solutions to biomedical complications. This kind of applied research strives to offer strategies to questions surrounding the etiology, pathology, diagnosis, prevention and treating cancer.
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