New Drug Offer Hope To Patients With Late Stage Prostate Cancer
At present, metastatic and hormonal-refractory prostate cancer patients who have failed 1st line chemotherapy will be given mitoxantrone plus prednisone as the salvage therapy. However, mitoxantrone plus prednisone is not very effective in controlling metastatic prostate cancer. Now, a new drug developed by sanofi-aventis might offer hope to patients who have failed 1st line chemotherapy (docetaxel plus prednisone).
The new drug called cabazitaxel was investigated in the TROPIC trial that included 755 advanced prostate cancer patients who have failed 1st line docetaxel chemotherapy. Half of the patients in the trial received combination of cabazitaxel and prednisone while the other half received mitoxantrone and prednisone.
After one year of treatment, men in the cabazitaxel arm had an overall median survival of 15.1 months, compared to 12.7 months among men in the mitoxantrone arm. Patients who received the combination treatment with cabazitaxel also experienced a significant increase in median progression-free survival, 2.8 months vs. 1.4 months. Note that cabazitaxel was also associated with a 30 percent reduced risk of dying.
Like other chemotherapies, cabazitaxel was associated with side-effects such as low white blood cells (81.7%), low white blood cells with fever (7.5%), diarrhea (6.2%) and infections (10.2%).
This drug has not been approved by FDA, but is under the fast track approval process - process designed to expedite the review of drugs being developed for serious diseases with the potential to address an unmet medical need. To participate in clinical trials, you may visit www.clinicaltrials.gov for details and contact your physicians.
http://en.sanofi-aventis.com/binaries/20100304_Asco_GU_en_tcm28-27547.pdf
Please visit us at healthreason.com for more articles like this.
Questions and Answers
The FDA or US Food and Drug Administration granted approval of Jevtana by Sanofi Aventis. Sanofi's Jevtana in combination with prednisone for the treatment of metastatic hormone-refractory prostate cancer (mHRPC) patients resulted in a statistically significant reduction in the risk of death compared to treatment with mitoxantrone and prednisone.
Cancer translational research brings together scientists' and clinicians' suggestions to develop solutions to biomedical complications. This kind of applied research strives to offer strategies to questions surrounding the etiology, pathology, diagnosis, prevention and treating cancer.
Orbs are actually a lumpectomy or quadrantectomy combined with rotating the breast tissue or mobilize the flap into the cavity of the surgery time fill is removed. It also includes the comparative change in shape and size is doing in relation to breast and moved if necessary, does not affect the conversion of the breast. The deferred plan the reconstruction is not part of endoplasmic techniques. Both procedures are performed by specific thoracic surgeons.
What every woman fears for is losing her self confidence , losing hope and losing her personality. The term "Breast Cancer" is a very negative word and that it creates negative vibrations in her heart. So, to make her comfortable with the basics of breast cancer and to make her means any woman understand that this type of cancer is the least dangerous than all cancers and that if it is detected early then you will fight with it successfully. Causes, Symptoms, treatment, discussed in detail.
Mesothelioma is a rare cancer that originates in the mesothelium. The mesothelium is the protective lining that covers the body's internal organs. Mesothelioma occurs when the mesothelium cells start to divide uncontrollably.
Chemotherapy is a treatment for killing cancerous cells which is given intravenous or extra-venous to the cancer patient. Even breast cancer patients have to go through the treatment. This treatment mainly focuses on the cancerous cells that are spread in the blood stream in the whole body . If any cancerous cells are there then they are killed by the chemotherapy medicine. The medicine is very costly and it has to be taken for one or two days continuously for every 21 days .
Treatment options for stage 4 melanoma - skin cancer.
Discuss this Article
