In US alone, more than half population is either overweight or obese. The statistic is alarming as obesity is associated with many chronic diseases including cardiovascular disorders, diabetes and others. It’s a need to identify genes that have prominent influences on obesity.
INSIG2 gene induced by insulin would inhibit the fatty acid and cholesterol synthesis. People with a sequence variation near the gene would exhibit more fat accumulation, as the normal functional gene could not complete its potential.
In three rare diseases of severe fat malabsorption, chylomicron retention disease (CMRD), Anderson disease and CMRD with Marinesco Sjogren syndrome, the Sar1b protein required for all dietary fat absorption could not work normally because of genetic mutation.
Gene variant FTO that is susceptible to type 2 diabetes can be found among over half of European population who is linked with obesity causes. If a person with two copies of FTO variant is likely to weigh 3 kilos more than a normal person, and person with only one copy there are more likely to weigh 1.2 kilos more.
The human lipin gene might be a candidate for obesity was excess levels in fat tissue or skeletal muscle will promote the condition. Deficiency in lipin levels would prevent normal development of mature fat cells.
Another mutant gene, ENPP1 which presents in 20% Caucasians and 50% of black people, will block insulin from binding in pancreas and the brain. Thus, the insulin resistance will store excess glucose production from liver as layers of fat and diminish insulin secretion that will lead to increased risk of type 2 diabetes.
GAD2, a gene found on chromosome 10 can speed up the production of a chemical transmitter in the brain, GABA, which stimulates appetite. One form of the gene appeared to protect some people against obesity, while another form increased the risk of the disorder.
About 20 genes maybe involved in causing common obesity, but genetics alone cannot fully account for a worldwide obesity trend in recent decades.
Got a Question? Ask.
Ask the community a question about this article:
Frequently Asked Questions
Is obesity good or bad for the economy
By: lizzleliz1 | 20-11-2007
is obesity good or bad for the economy
Hila Elmalich Dies at 60 Pounds of Anorexia
By: DD.Suzan | 20-11-2007
A model died last week weighing barely 60 pounds. Do you think being 60 pounds is better than being 260?
Am I Super Obese
By: fatgirl | 15-11-2007
is 560 pounds super obese?
What country has the most overweight/obese people (relative to its size)?
By: JenniferL | 14-11-2007
what country has the most overweight/obese people (relative to its size)?
Overeating
By: estherl | 13-11-2007
what is the best way to combat overeating
Spirulina intake for a vegan
By: BigRedClown | 12-11-2007
Being a vegan, is taking spirulina powder 2-3 times per day(1/2 tsp each time) close to enough to fulfill your daily requirements of iron, protein or vitamin B12?As it is I already have a fairly well rounded diet, eating many fruits and veg, seeds and nuts, but not so much grains.Thanks!
Q&A Powered by:
Latest Health Articles
Stress - Driving Them Away
By: Paul Hata | 21/08/2008
Chances are you will not be able to reduce your stress level overnight. Many of us have become quite used to stress on the road. However, by trying to make our trips as pleasant as possible, we can go a long way to lessening driving-induced stress.
Stress - Bring An End To The Meal-Time Rush
By: Paul Hata | 21/08/2008
Even if you don't have children, meal time can be major stress time. Your mate might become irritable while awaiting dinner, and you might be grumpy as well. Hunger can be a powerful motivator, but it can also be the cause of major stress. Sometimes, you might find it difficult to concentrate as your stomach is growling.
Mind Over Matter At Vital Times
By: Catherine Harvey | 21/08/2008
A look at one mans survival with the power of the mind after a catastrophic personal injury.
Stress - Are Your Kids Stressing You Out
By: Paul Hata | 21/08/2008
While you can guide your child, you cannot expect to control him or her, particularly when your child reaches the teenage years. Therefore, you have to learn to somehow manage the stress of parenthood before it gets the better of you.
At Home DNA Testing is Here
By: Jason Kay | 21/08/2008
You can't watch a crime drama on TV, or the news (think Anna Nicole Smith) for very long nowadays without hearing about DNA. DNA testing can tell who fathered a child. It can rescue an innocent inmate from prison, or prove the case against a criminal. DNA testing can give...
Fighting Cancer From Within
By: Catherine Harvey | 21/08/2008
A look at the research that is being carried out into the treatment of cancer and how new findings hope to secure a way of using the bodies own defence system to beat the killer disease.
The Health Benefits of Vitamin C
By: Paul Hata | 21/08/2008
The C vitamin is also an antioxidant for the body and helps other vitamins and minerals to be absorbed better. Folic acid and iron, for example, need the C vitamin to maximise their usefulness. The more C vitamin that the body has, the better its defence against colds and other common ailments.
Massage Therapy - History and Development
By: Paul Hata | 21/08/2008
During 500 BC-50 AD, the Greek and Romans used massage on Olympic athletes and to relieve neuralgia and epileptic seizures. Hippocrates, the father of medicine, incorporated massage in medicine. In 130 AD-201 AD, Galen, a Greek physician from the school of gladiators who were rubbed before fighting wrote a book on manual medicine.
More from J.J. Yong
How to Prepare for the Gmat Examination
By: J.J. Yong | 19/05/2008 | College and University
You've heard all about how hard the GMAT is but you know that it is the only thing that stands between you and the top business schools. What you need to do is prepare for the exam as well as possible. There are some great tools out there that can help you prepare for and pass the exam with flying colors.
Top Ten Reasons Why I Should Start Taking the Gmat Examtop Ten Reasons Why I Should Start Taking the Gmat Exam
By: J.J. Yong | 19/05/2008 | College and University
Many people put off taking the Graduate Management Admission Test a.k.a. GMAT until the last moment. There are many reasons why you should starting taking the GMAT now, or at least take GMAT practice tests. The GMAT is a big step for a lot of people, and it may be a requirement for you to get into a graduate program.
Challenges in an Online MBA Course Program
By: J.J. Yong | 19/05/2008 | Online Education
Many people think that when they sign up for an online MBA course that they will be able to fly through the course and come out the other side with their Master of Business Administration without working. The fact of the matter is that there are a lot of challenges involved in taking an online course and you need to be prepared for them.
How to Become an Online MBA Course Graduate
By: J.J. Yong | 19/05/2008 | Online Education
Have you had someone tell you that just received their certified MBA? Are you now wondering how this person was able to complete their education while holding down a job? If you asked you would probably find that your friend graduated from an online course as this is a way that many people are able to get their degree and better their life, all without stepping foot into a classroom.
What Else Do I Need to Face When I'm Short Listed for an Online MBA Course?
By: J.J. Yong | 19/05/2008 | Online Education
When you are interested in an online MBA course you may need to apply in advance to hopefully be accepted. The time will come when the online business school will announce who has been accepted and who has been short listed. If you have been short listed you may be wondering what else you need to face in the process of trying to get your post-graduate business course.
Stop Worrying About Being Obsolete by Taking an Online MBA Course
By: J.J. Yong | 19/05/2008 | Online Education
When you are going through schooling you always have to think about getting an education but you also have to make sure that you are getting an education that is relevant to what is going on in the world right now. You can stop worrying about being obsolete when you take an online MBA course.
Secrets of Passing the Online MBA Exam
By: J.J. Yong | 19/05/2008 | Online Education
Do you need to take the online MBA exam and you are wondering how you can possibly pass the course to get the certified MBA that you need to get where you want to go in life? The secrets of passing an online MBA course or exam are the same, it's all about preparation.
Online MBA Course - Your Ticket to Success
By: J.J. Yong | 19/05/2008 | Online Education
Did you finish up your bachelors degree a few years ago and decide that you needed to get a job to pay off some debt and then you would go back and get your MBA? Have you waited too long to go back and now you are starting to feel like you'll never reach the level of success that you had always hoped for?
Health 
