Flodol Glucosamine

<h1>Flodol Glucosamine</h1>Author: <a title="Ivan S. Pullicino B.Pharm. (Hons.) M.Sc." href="http://www.articlesbase.com/authors/ivan-s.-pullicino-b.pharm.-(hons.)-m.sc./59916.htm">Ivan S. Pullicino B.Pharm. (Hons.) M.Sc.</a>       <img src="http://www.altacare.com/uploads/news/2663_320x500_10.jpg" />   Following are the details of a randomized, double blind study on the effects of a topical cream containing Glucosamine Sulfate for osteoarthritis of the knee. The study was done by Marc Cohen, Rory Wolfe, Trudy Mai and Daniel Lewis. Objective To assess the ability of a topical preparation of glucosamine sulfate and chondroitin sulfate to reduce pain related to osteoarthritis (OA) of the knee. Methods 63 patients were randomized to receive either a topical glucosamine and chondroitin preparation or placebo to be used as required over an 8-week period. Efficacy was assessed using a visual analog scale (VAS) for pain as well as the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the SF-36 questionnaire. Results VAS scores indicated a greater mean reduction in pain for the glucosamine/chondroitin preparation group (mean change - 3.4cm, SD 2.6cm) compared to the placebo group (mean change - 1.6cm, SD 2.7cm) after 8 weeks. After 4 weeks the difference between active and placebo groups in their mean reduction from baseline was 1.2 (95 per cent CI 0.1 to 2.4, p = 0.03) and after 8 weeks was 1.8 (95 per cent CI for difference between groups, 0.6 to 2.9cm; p = 0.002). Conclusion Topical application of glucosamine and chondroitin sulfate is effective in relieving the pain from OA of the knee and improvement is evident within 4 weeks. Glucosamine and chondroitin sulfate have been consistently shown to be agents of low toxicity that may relieve the pain and joint stiffness associated with osteoarthritis (OA). Longterm use of glucosamine may reduce radiographic progression of OA of the knee, suggesting it may be a chondroprotective, disease modifying agent in OA of the knee. Although rapidly absorbed from the gastrointestinal tract, pharmacokinetic data show that when administered orally, glucosamine is subject to uptake and degradation by the liver and uptake into non-joint tissues so that the dose reaching the articular cartilage is a fraction of a percentage of the oral dose. While glucosamine has been shown to be active when given intramuscularly, direct topical application into the dermis surrounding an affected joint may potentially deliver a more concentrated dose to the affected area. Chondroitin sulfate has also been shown to be effective in reducing OA pain and to enhance the pain relieving action of glucosamine, despite poor gastrointestinal bioavailability when administered orally. Chondroitin sulfate may further act as a carrier substance to enhance dermal penetration of topical substances. The study examines the use of a topical glucosamine/chondroitin sulfate preparation containing camphor and peppermint oil in relieving pain from OA of the knee. Source: The Journal of Rheumatology 2003; 30:3, pgs 523-528. <a href="http://www.altacare.com"><a href="http://www.altacare.com" target="_blank">www.altacare.com</a></a>  About the Author: ALTA CARE Laboratoires, an independent multinational company with head offices on Avenue Champs-Elysees, Paris. Founded by pharmacists who work in the EU, With over twenty years of experience in professional consultancy ALTA CARE Laboratoires over the years has produced products for other multinational companies.
Recently, the group of pharmacists and doctors decided not to work exclusively for third parties but also to build its own brand ALTA CARE Laboratoires.

ALTA CARE Laboratoires immediately expanded its know how in the manufacture of nutriceuticals and phyto-therapy to produce an exclusively innovative line of products specializing in food supplements, luxury skincare products and aesthetic machinery.

ALTA CARE Laboratoires full range of products can be viewed on <a href="http://www.altacare.com" target="_blank">www.altacare.com</a>Article Source: <a href="http://www.articlesbase.com/">ArticlesBase.com</a> - <a href="http://www.articlesbase.com/health-articles/flodol-glucosamine-917081.html" title="Flodol Glucosamine">Flodol Glucosamine</a>

Following are the details of a randomized, double blind study on the effects of a topical cream containing Glucosamine Sulfate for osteoarthritis of the knee.

The study was done by Marc Cohen, Rory Wolfe, Trudy Mai and Daniel Lewis.

Objective
To assess the ability of a topical preparation of glucosamine sulfate and chondroitin sulfate to reduce pain related to osteoarthritis (OA) of the knee.

Methods
63 patients were randomized to receive either a topical glucosamine and chondroitin preparation or placebo to be used as required over an 8-week period. Efficacy was assessed using a visual analog scale (VAS) for pain as well as the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the SF-36 questionnaire.

Results
VAS scores indicated a greater mean reduction in pain for the glucosamine/chondroitin preparation group (mean change - 3.4cm, SD 2.6cm) compared to the placebo group (mean change - 1.6cm, SD 2.7cm) after 8 weeks. After 4 weeks the difference between active and placebo groups in their mean reduction from baseline was 1.2 (95 per cent CI 0.1 to 2.4, p = 0.03) and after 8 weeks was 1.8 (95 per cent CI for difference between groups, 0.6 to 2.9cm; p = 0.002).

Conclusion
Topical application of glucosamine and chondroitin sulfate is effective in relieving the pain from OA of the knee and improvement is evident within 4 weeks.

Glucosamine and chondroitin sulfate have been consistently shown to be agents of low toxicity that may relieve the pain and joint stiffness associated with osteoarthritis (OA). Longterm use of glucosamine may reduce radiographic progression of OA of the knee, suggesting it may be a chondroprotective, disease modifying agent in OA of the knee.

Although rapidly absorbed from the gastrointestinal tract, pharmacokinetic data show that when administered orally, glucosamine is subject to uptake and degradation by the liver and uptake into non-joint tissues so that the dose reaching the articular cartilage is a fraction of a percentage of the oral dose. While glucosamine has been shown to be active when given intramuscularly, direct topical application into the dermis surrounding an affected joint may potentially deliver a more concentrated dose to the affected area.

Chondroitin sulfate has also been shown to be effective in reducing OA pain and to enhance the pain relieving action of glucosamine, despite poor gastrointestinal bioavailability when administered orally. Chondroitin sulfate may further act as a carrier substance to enhance dermal penetration of topical substances. The study examines the use of a topical glucosamine/chondroitin sulfate preparation containing camphor and peppermint oil in relieving pain from OA of the knee.

Source: The Journal of Rheumatology 2003; 30:3, pgs 523-528.

www.altacare.com

Ivan S. Pullicino B.Pharm. (Hons.) M.Sc.

ALTA CARE Laboratoires, an independent multinational company with head offices on Avenue Champs-Elysees, Paris. Founded by pharmacists who work in the EU, With over twenty years of experience in professional consultancy ALTA CARE Laboratoires over the years has produced products for other multinational companies. Recently, the group of pharmacists and doctors decided not to work exclusively for third parties but also to build its own brand ALTA CARE Laboratoires. ALTA CARE Laboratoires immediately expanded its know how in the manufacture of nutriceuticals and phyto-therapy to produce an exclusively innovative line of products specializing in food supplements, luxury skincare products and aesthetic machinery. ALTA CARE Laboratoires full range of products can be viewed on www.altacare.com

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