Dr. Darlene E McCord is one of the two founders of McCord Research. As senior researcher, she brings a unique blend of scientific credentials to the position. Through her leadership, the company has achieved worldwide recognition in the OTC Drug and Medical Device categories. Her field of specialty is corneotherapy, focusing on the transport of small molecules across the stratum corneum for treatment of skin disorders associated with distressed and wounded skin. Dr. Darlene E McCord is widely published on subjects related to immunodermatology and corneotherapy.
There are two distinct mechanisms for cell death. Apoptosis is the result of “normal” or programmed cell death. Through this physiological process cells are routinely eliminated, giving balance to the proliferation of new cells. During apoptosis the outer membrane of the cell forms “bubbles” known as blebs. The content of the cells becomes incased in the blebs. The blebs separate from the cell and are digested by nearby cells or macrophages. This orderly process greatly reduces toxicity to surrounding cells.
Necrosis is the other form of cell death. This is not a programmed event and is known as “accidental” death. This pathological process occurs when cells are exposed to extreme stress, chemical insult, and resultant free radical damage. The early stages of necrosis involve a swelling of the cell called oncosis. During oncosis the cell and its organelles begin to swell due to an exchange in the cell’s potassium to sodium ratios. Necrosis, after the oncosis stage, is an explosive event where the cells contents stream directly into the surrounding cells environment causing damage and an immune response.
Controlling necrosis during the early oncosis stage is important. Up to this point, necrosis is a reversible event. Reversal is possible when the cell’s environment is changed through the reduction of free radicals and other toxins. Wound repair is, in part, dependent upon reversing the risks associated with “accidental” cell death.
When the cell remains in the GO cell cycle stage and does not advance to the G1 stage of proliferation, it is known as quiescence. The cellular quiescent-to-proliferation process is normal. Quiescence allows the cell to rest and await the signal to divide again as part of the cell cycle. When the cell’s environment is not conducive to cell division, the cell is given a signal(s) to wait for “instructions” that it is safe to divide. The longer a cell stays in abnormal quiescence the more likely it becomes that the cell will die via necrosis. Just as with early stage necrosis, early quiescence is a reversible event that can be corrected by changing the cell’s environment. Reduction of free radicals in the cell’s environment is critical to the reversal process.
Darlene McCord, Ph.D., FAPWCA
- Related Videos
- Related Articles
- Ask / Related Q&A
- Apoptosis: New Approaches to Cancer Therapy
- Apoptosis Programmed Cell Death
- The Amazing Healing Power of the Acai Berry
- Cell Death and Proliferation
- Diabetic Skin Care
- An effective way of reversing the malignant process
- Dr. Darlene Mccord Discusses Nutrients for Skin Care
- Mesothelioma Treatment-What are the Emerging New Approaches?
Skin Care Ingredients – For Better Of For Worse?
By: Naomi Andrews | 24/12/2009Just as some skin care ingredients are considered good for the skin, there are other ingredients that are infamous for the side effects they have. While some are known to cause cancer, some are accused of over-drying the skin.
Cupuacu Vital - How To Stay Young Looking Review
By: Sabrina Alba | 24/12/2009Would you like to have a healthy, glowing and young looking skin without going through any skin treatment? Do you want to say goodbye to all of your wrinkles and other sings onf aging in just a few weeks so that you will feel more confident about your flawless and beautiful skin?
Cupuacu Vital - Anti Aging Nutritional Supplements
By: Sabrina Alba | 24/12/2009Have you been hearing tons of good new about anti aging products on how it can effectively help you erase all the signs of aging on your skin in just a short span of time? Well, you should actually believe it because there are tons of people who were also once like you and they were also worried about their skin.
Cupuacu Vital - How To Keep Young Looking
By: Sabrina Alba | 24/12/2009Would you like to know more information about the most effective ways on making yourself look younger than ever? Are you worried because as each day goes by you feel that you're look older and older and it bothers you so much that you're too shy to show your face in front of all the people already?
How Does Exercise Affect Your Cholesterol Levels
By: Ali Khan | 23/12/2009Everyone knows that exercise is an important part of a healthy lifestyle, even if some people choose not to exercise at all. The fact that only 10% of American adults exercise at least three times a week, however, may indicate that many people do not realize how beneficial exercise can truly be.
The Main Signs Of High Blood Pressure
By: Ali Khan | 23/12/2009High blood pressure is known as a silent murderer. And probably most do not even think about your blood pressure. However, high blood pressure can be very serious. There are some symptoms that may indicate that you have high blood pressure, and may prevent you from having a stroke. So read on, because it can save your life or the life of someone you know.
How to Improve Your Skin with Night Time Skin Care
By: Danna Norek | 23/12/2009Many people don't know that the night time is the best time to apply your strongest, most potent skin care treatments for maximum impact. Read on for why if you are not using this time to your utmost benefit, your skin is missing out on the best time to repair, rejuvenate and reverse the signs of aging.
Six Steps To Improve Your Body Image
By: Ali Khan | 23/12/2009A positive body image is that we must all fight. This is when you know yourself and who you are. You have a real sense of its size, shape and weight. You look like you're in the present. You agree to itself, but may be overweight. You believe in yourself and love yourself while striving for something better. When you have a positive body image, no time spent obsession with food, weight, calories, exercise, etc. You are proud of who you are and feel comfortable in your own body.
Skin Disease and Treatment With Olivamine
By: Darlene McCord | 16/05/2008 | Skin CareEczema Immunopathogenesis. While not fully understood, substance P (SP) and C nerve fibers are implicated in pruitoceptive itch and nociceptive pain. This paper will elucidate C nerve fiber and SP involvement.
Implications of Corneotherapy and Reduction of Excessive Transepidermal Water Loss by Darlene Mccord, Ph.d
By: Darlene McCord | 16/05/2008 | Skin CarePreventive corneotherapy, a term coined in the 1990s by Albert Kligman, M.D., Ph.D., is becoming one of the most important principles of treatment in advanced skin care. The object of corneotherapy, topical delivery of active concentrates through the skin, is skin barrier homeostasis. The ultimate development in the quest for understanding the stratum corneum is corneotherapy, focusing therapy toward correcting the defective horny layers.
Skin Cleansing Tips From Dr. Darlene Mccord
By: Darlene McCord | 14/05/2008 | Skin CareOne area of skin care that is often not well thought out is cleansing. During this process the skin can either be nourished or further damaged. Unfortunately, the later is more often the case.
Dr. Darlene Mccord Discusses Nutrients for Skin Care
By: Darlene McCord | 14/05/2008 | Skin CareDr. Darlene McCord discusses nutrients critical for proper skin care.
Matching Emollient Neonatal Skin Care Product Selection With Changes in the Standard of Care
By: Darlene McCord | 13/05/2008 | Skin CareThe Evidence-Based Clinical Practice Guideline for neonatal skin care, including a Neonatal Skin Condition Scale (NSCS), has been validated by the Association of Women’s Health, Obstetric and Neonatal Nurses (AWHONN) and the National Association of Neonatal Nurses (NANN).
Cell Death and Proliferation
By: Darlene McCord | 13/05/2008 | Skin CareDr. Darlene McCord, Ph.D., FAPWCA discusses cell death and proliferation.
Commonly Used Baby Skin Care Products Contain Chemicals That Put Infants at Substantial Risk
By: Darlene McCord | 13/05/2008 | Skin CareThe arrival of a new baby brings many concerns and issues for new and incumbent parents. While new parents are faced with a myriad of issues for the first time, incumbent parents have to deal with the information explosion and change in thought on issues which have evolved since their first parenting experience. Chief among the issues for both new and incumbent parents is the proper care of newborn skin.