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FACTS ABOUT ARTHROLEVE UHI™

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What is Arthroleve™?

Arthroleve UHI™ brings you the best in natural joint pain relief and cartilage repair without dangerous side effects.† Independent clinical trials report that the ingredients in Arthroleve™

· relieve bone and joint pain†

· support cartilage building and repair†

· improve joint function and stiffness†

Our physicians and pharmacologists formulated Arthroleve™ after months of reviewing university research studies worldwide. The result is a powerful nutraceutical that’s as effective as other joint pain products without risking damage to the digestive system, heart, liver, or other internal organs.†

Potent yet safe, each easy-to-swallow Arthroleve UHI™ caplet is made in America and meets stringent GMP pharmaceutical quality standards. It is available without a prescription.

Who should take Arthroleve™?

Arthroleve™ is recommended for adults suffering from

· joint or bone pain caused by trauma or excessive use

· joint or bone pain caused by strenuous or repetitive activity

· non-specific lower back pain (NSLBP)

· weakened bones and joints due to age or injury

Arthroleve™ is also beneficial for individuals who want to maintain and strengthen healthy joints.

What are the ingredients in Arthroleve™?

Each Arthroleve™ caplet contains 100 mg of S-adenosyl-l-methionine, 166.5 mg of Harpagophytum procumbens, and 200 mg of glucosamine sulfate.

S-adenosyl-l-methionine is a substance that occurs naturally in all living cells. It is formed from methionine (an essential amino acid) and adenosine triphosphate. Multiple clinical trials have shown that S-adenosyl-l-methionine reduces joint pain and inflammation as effectively as leading prescription products, and offers additional benefits for mood support and liver function.†

Evidence suggests that S-adenosyl-l-methionine may play a role in reducing inflammation, increasing proteoglycan synthesis, and/or reducing pain (Najm et al, 2004). It is sold as a drug in Europe.

Harpagophytum procumbens (Hp) is from the devil’s claw plant, a medicinal herb used for generations in Africa and Europe for treating rheumatic complaints. It is believed to work in the same way as Cox-2 anti-inflammatory drugs. In clinical research, Harpagophytum procumbens has proven highly effective in reducing non-specific lower back pain. One recent study found that 20 percent of patients treated for low back pain with Harpagophytum procumbens were completely pain free after six weeks of treatment.

Glucosamine, derived from the exoskeletons of shrimp, crab, lobster, and other shellfish, is an essential material for repairing and maintaining cartilage. It lubricates joints by helping cartilage absorb and hold water. Research shows that glucosamine alleviates pain and protects joints as effectively as leading joint pain treatments, but without the dangerous side effects.

How does Arthroleve™ work?

Arthroleve™ helps repair and protect chondrocytes, the cells that produce joint cartilage. Its natural compounds suppress chemicals (matrix degrading enzymes) that interfere with cartilage production and contribute to pain and inflammation.

At the same time, Arthroleve™ nourishes the live chondrocytes with essential building blocks for new cartilage, thus supporting the repair and regeneration of connective tissue in the joint.

How can joint trauma cause chronic pain?

The cells that produce joint cartilage (chondrocytes) normally die off at a rate of less than one percent. However, within 48 hours of trauma to a joint, the cell death rate shoots up dramatically—sometimes rising as high as 37 percent. This increase in cell death stimulates enzymes that attack the cartilage in the joint. The damage to the cartilage “cushion” weakens the joint and can lead to chronic pain.

Who should not take Arthroleve™?

Arthroleve™ should not be used by people with ulcers, gallstones, diabetes, or allergies to shellfish. It has not been tested in children.

Consult a physician before use if you are pregnant or nursing; have a history of depression, bipolar disorder, or other psychiatric illness; or are taking cardiac medication, blood thinners, or MAOI antidepressants.

How much should I take?

The baseline dosage is one caplet twice daily. For additional benefit, you may increase the dose to two caplets twice daily.

Arthroleve™ is best taken on an empty stomach, but may be taken with food. Antacids may reduce the product’s effectiveness.

What are the possible side effects?

No serious side effects have been reported for the ingredients in Arthroleve™. Higher dosages may cause mild or occasional gastrointestinal upset, mainly diarrhea, in some individuals.

If you experience an allergic reaction, discontinue use and consult a physician.

What is your guarantee?

University Health Industries’ products are backed by our 100% money-back guarantee for first-time orders. If you are not completely satisfied, simply return the unused product within 30 days and we’ll refund your purchase price, less shipping and handling.

How was Arthroleve™ developed?

Physicians and pharmacologists developed Arthroleve™ using the principles of evidence based medicine (EBM) and the results of clinical research from university laboratories worldwide.



Evidence based medicine involves examining a broad spectrum of evidence—such as meta-analyses, systematic reviews of existing research, randomized controlled trials, cohort studies, and other methods of inquiry—to make decisions about effective treatment and patient care.

What is a meta-analysis?



A meta-analysis collects data from many similar research studies, then analyzes the pooled data for statistical significance.



What scientific evidence was used to create Arthroleve™?

Below is a representative sample of the scientific evidence used in formulating patent-pending Arthroleve™. The reference sources are provided at the end of this booklet.

S-adenosyl methionine

In a double-blind crossover trial, the authors concluded that S-adenosyl methionine is as effective as celecoxib (Celebrex®) in the management of symptoms of knee osteoarthritis (Najm WI et al, 2004).

A meta-analysis concluded that S-adenosyl methionine appears to be as effective as NSAIDS in reducing pain and improving functional limitation in patients with osteoarthritis without the adverse effects often associated with NSAID therapies (Soeken et al, 2003).

S-adenosyl methionine plays an important role in the liver, acting as a protective agent for oxidative stress. Patients with liver disease often become deficient and may benefit from the administration of this supernutrient (Liber, 2002).

Harpagophytum procumbens

A recent double-blind pilot study comparing Harpagophytum procumbens to rofecoxib (Vioxx®) found both treatment groups responded equally well in the treatment of lower back pain. The authors also found that 20 percent of the patients treated for low back pain with Harpagophytum procumbens were completely pain free after six weeks of treatment (Chrubasik et al, 2003).



In a recent review of the literature on Harpagophytum procumbens, the study authors concluded that there is strong evidence for its effectiveness in treating non-specific lower back pain (NSLBP) and moderate evidence for its effectiveness in treating osteoarthritis pain (Gagnier et al, 2004).



Glucosamine sulfate

In Drug Discovery Today, a 2004 review article concluded that glucosamine sulfate was effective in narrowing joint space, as a structure-modifying agent to protect joints, and in symptomatic relief of arthritic pain (Curtis et al, 2004).



A recent review of the scientific literature published in the Annals of Pharmacotherapy concluded that available evidence suggests glucosamine sulfate may be effective and safe in improving symptoms and delaying the progression of knee osteoarthritis (Poolsup et al, 2005).

What is the NPA TruLabel Program?

The Natural Products Association (NPA) TruLabel program is the industry’s most expansive and successful self-regulatory program.

University Health Industries and other NPA members voluntarily pay for random monitored tests of their products by independent laboratories. If a test reveals any deficiency in product quality or accuracy in labeling, NPA immediately alerts the member company and expects it to take corrective action. NPA revokes the membership of any company that does not comply.

Who is University Health Industries?



Every year university labs around the globe identify research and test natural compounds and formulations which have the potential to improve our quality of life.

The majority of these potentially life changing discoveries are never commercialized for the benefit of the public.



University Health Industries, in collaboration with university based researchers worldwide, researches and identifies those compounds that have proven evidence based effects and have the greatest potential for improving our lives.



University Health Industries’ mission is to deliver the latest advances and discoveries in natural compounds packaged in our unique patented formulations and delivered to satisfy the needs of consumers for the promotion of health for many common age-related health concerns.



UHI is a proud American company with offices and manufacturing facilities in Boca Raton, Florida. All of our products are GMP-approved and made in the United States to ensure they adhere to standards the American public can trust.

What other nutraceuticals are available from UHI?

University Health Industries recently introduced three additional products, each developed with the same quality and efficacy standards as Arthroleve™:



· Zenstral PMS™ for premenstrual syndrome and premenstrual dysphoric disorder (PMDD)†

http://www.zenstralpms.com

· Premium SAMe UHI™ for mood support†

· Cold & Flu RMD for immune system support and relief from the common cold†





Our physicians and pharmacologists are hard at work creating additional evidence-based nutraceutical products. For more information, or to receive product announcements and special offers by email, please visit www.arthroleve.com or www.universityhealthindustries.com.

Scientific References



Chrubasik S, Model A, Black A, Pollak S. A randomized double-blind study comparing Doloteffin® and Vioxx® in the treatment of low back pain. Rheumatology. 2003:32;141-8.

Gagnier JJ, Chrubasik S, Manheimer E. Harpophytum procumbens for osteoarthritis and low back pain: a systematic review. BMC Complement Altern Med. 2004 Sep 15;4:13.

Poolsup N, Suthisisang C, Channark P, Kittikulsuth W. Glucosamine long-term treatment and the progression of knee osteoarthritis: Systematic review of randomized controlled trials. The Annals of Pharmacotherapy. 2005 June;39:1080-87.

Curtis CL, Harwood JL, Dent CD, Caterson B. Biological basis for benefit of nutraceutical supplementation in arthritis. Drug Discovery Today. 2004;9:16572.

Bressa GM. S-adenosyl-l-methionine (SAMe) as antidepressants: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14.

Najm WI, Reinsch S, Hoehler F, Tobis JS, Harvery PW. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. BMC Musculoskelet Disord. 2004 Feb 26;5(1):6.

Liber CS. S-adenosyl-L-methionine: its role in the treatment of liver disorders. AM J Clin Nutr. 2002;76(5):1183s-7s.

Setty AR, Sigal LH. Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects. Semin Arthritis Rheum. 2005 Jun;34(6):773-84.

Jacobsen S., Dannekiold-Samsoe B, Andersen RB. Oral S-adenosylmethionine in primary fibromyalgia. Double-blind clinical evaluation. Scandinavian Journal of Rheumatology. 1991;20(4):294-302.

Williams Al, Girard C, Jui D, Sabrina A, Katz DL. S-adenosylmethionine (SAMe) as treatment for depression: a systematic review. Clinical & Investigative Medicine – Medecine Clinique et Experimentale. 2005 June;28(3):132-9.

Soeken KL, Lee W, Bausell R, Anelli M, Berman BM. Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis. ACP J Club. 2003 Jan-Feb;138(1):21.

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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